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Interestingly, Gilbert’s syndrome subjects exhibit enhanced expression of PPARα, most likely from increased plasma bilirubin levels [55]

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When NKG2D and DNAX accessory molecule-1 (DNAM-1) on the surface of human NK cells bind to their ligands on the surface of GBM cells, they can trigger NK cell cytotoxicity and cause GBM cell death (228, 229)